The incidence of lung neoplasms is increasing in Brazil and in the world, probably as a result of the increase in smoking. Due to the greater number of cases, atypical presentations appear. We report the case of a 66-year-old hypertensive male smoker who presented progressive proximal muscular weakness and, in two months, evolved to dysphagia, dysphonia, and V-shaped skin lesions on the chest. A chest X-ray showed a spiculated pulmonary nodule in the right upper lobe. The biochemical analysis revealed elevated creatine kinase levels. After complementary tests and biopsies, the patient underwent right upper lobectomy. Histopathology showed a moderately differentiated adenocarcinoma. The overall analysis of the case and a review of the literature allow us to suggest that the clinical profile of the patient was a result of an overlap of two paraneoplastic syndromes (dermatomyositis and Lambert-Eaton myasthenic syndrome) secondary to lung adenocarcinoma.
CITATION STYLE
Milanez, F. M., Pereira, C. A. D. C., Trindade, P. H. D. M., Milinavicius, R., & Coletta, E. N. A. M. (2008). Lung adenocarcinoma, dermatomyositis, and Lambert-Eaton myasthenic syndrome: A rare combination. Jornal Brasileiro de Pneumologia, 34(5), 333–336. https://doi.org/10.1590/s1806-37132008000500014
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