microRNAs: Novel regulators of the TGF-β pathway in pancreatic ductal adenocarcinoma

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Abstract

We identified that transforming growth factor-β (TGF-β) induces long non-coding RNA (lncRNA) MIR100HG along with its host microRNAs (miRNAs) miR-100 and miR-125b, to regulate its response in pancreatic ductal adenocarcinoma (PDAC). Importantly let-7a, despite originating from MIR100HG, remains unchanged because post-transcriptionally repressed by lin-28 homolog B (LIN28B). A novel method for global miRNA-target discovery identified that miR-100/125b regulates crucial PDAC pathways.

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Ottaviani, S., & Castellano, L. (2018). microRNAs: Novel regulators of the TGF-β pathway in pancreatic ductal adenocarcinoma. Molecular and Cellular Oncology, 5(6). https://doi.org/10.1080/23723556.2018.1499066

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