Beclin 1 is the first mammalian autophagy protein identified as a novel Bcl-2-interacting protein. Subsequent studies have demonstrated that this landmark protein is essential for autophagy. By investigating the interaction between Bcl-2 and Beclin 1, key molecular mechanisms of mammalian autophagy regulation have been discovered. In this chapter, we will first review the discovery of Beclin 1 and then focus on the mechanisms of Bcl-2 and Beclin 1 regulation and their effect on autophagy regulation. Finally, we summarize the evidence related to the interaction of Bcl-2 and Beclin 1 and the involvement of these proteins in human diseases such as cancers, neurodegenerative diseases and infectious diseases.
CITATION STYLE
Xu, H. D., & Qin, Z. H. (2019). Beclin 1, Bcl-2 and Autophagy. In Advances in Experimental Medicine and Biology (Vol. 1206, pp. 109–126). Springer. https://doi.org/10.1007/978-981-15-0602-4_5
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