Antigen shedding into the circulation contributes to tumor immune escape

Abstract

Tumors employ various mechanisms to escape elimination by the immune system. In addition to the local induction of immunosuppressive cell types such as regulatory T cells or myeloid derived suppressor cells, tumor antigen shedding into the circulation may suppress antitumor CD8+ T-cell function via tolerogenic liver sinusoidal endothelial cells. © 2012 Landes Bioscience.