Abstract
Five new compounds-rhodimer (1), rhodiflavan A (2), rhodiflavan B (3), rhodiflavan C (4), and rhodacarpin (5)- A long with 16 known secondary metabolites, were isolated from the CH2Cl2-CH3OH (1:1) extract of the roots of Tephrosia rhodesica. They were identified by NMR spectroscopic, mass spectrometric, X-ray crystallographic, and ECD spectroscopic analyses. The crude extract and the isolated compounds 2-5, 9, 15, and 21 showed activity (100% at 10 μg and IC50 = 5-15 μM) against the chloroquine-sensitive (3D7) strain of Plasmodium falciparum.
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CITATION STYLE
Atilaw, Y., Muiva-Mutisya, L., Bogaerts, J., Duffy, S., Valkonen, A., Heydenreich, M., … Yenesew, A. (2020). Prenylated Flavonoids from the Roots of Tephrosia rhodesica. Journal of Natural Products, 83(8), 2390–2398. https://doi.org/10.1021/acs.jnatprod.0c00245
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