Canine Genetics Facilitates Understanding of Human Biology

Abstract

In the past 15 years the field of canine genetics has advanced dramatically. Dense comparative maps, production of ×1.5and ×7.5 genome sequences, SNP chips, and a growing sophistication regarding how to tackle problems in complex genetics have all propelled the canine system from a backwater to the forefront of the genomics landscape. In this chapter,we explore some of the critical advances in the field that have occurred in the past 5 years.We discuss the implications of each on disease gene mapping. Complex trait genetics and advances related to finding genes associated with morphology are also discussed. Finally,we speculate onwhat advances will likely define the field in the coming 5 years.