Keap1-Nrf2 System Plays an Important Role in Invariant Natural Killer T Cell Development and Homeostasis

Abstract

Keap1 and Nrf2 proteins work in concert to regulate redox balance in the cells. Pyaram et al. report that Keap1 governs NKT cell development and peripheral homeostasis by regulating proliferation and apoptosis. In an Nrf2-dependent manner, Keap1 also controls NKT cell metabolism, including glucose uptake and ROS.