In silico analysis of genomic data for construction of nuclear receptor network

Abstract

Availability of genome-wide information in public database provides unprecedented opportunity for developing new strategy to uncover potential interactions of members in large functional family. Here we describe a systematic strategy for constructing and analyzing potential interaction map to uncover novel interaction between nuclear receptors that may play important roles in human disease. This in silico approach can prioritize candidate interactions for further functional validation and assess its clinical relevance.