Dbait: A New Concept of DNA Repair Pathways Inhibitor from Bench to Bedside

Abstract

Biological systems need to be robust, both for survival of individuals under stress and for plasticity required for adaptation and evolution. In principle, networks can achieve robustness through redundancy. The most direct mechanism is simple substitutional redundancy, if a protein or a pathway are inactive another protein or pathway can substitute to perform the same function. Functional plasticity and redundancy are essential mechanisms underlying the ability to survive and maintain genome integrity. However, it is the cause of failure of many targeted therapies as alternative pathways can replace the function inactivated by the hit of the targeted enzyme.