INTRODUCTION: Angiostrongylus cantonensis meningoencephalitis is an emergent disease in the Americas. METHOD: Twelve children suffering from eosinophilic meningoencephalitis due to this parasite aged between 6-10 years were studied. Cerebrospinal fluid (CSF) and serum samples were taken simultaneously in the first diagnostic puncture at admission. RESULTS: All cases showed typical findings on the routine CSF and serum analysis: increased CSF total protein, increased Q (CSF/serum) albumin accompanied by eosinophilia in CSF. No intrathecal synthesis of immunoglobulins was found. Mean serum and CSF sICAM-1 values were 337.4 and 3.97 ng/mL. Qalbumin and QsICAM-1 mean values were 4.1 and 6.2 respectively. In 50% of the patients an increased brain-derived fraction of sICAM-1 was found. CONCLUSION: It may be suggested that a dynamic of the sICAM-1 brain derived fraction is perhaps associated to the immune response in the evolution of the disease. sICAM-1 may be an agent in negative feedback for eosinophils passage through the blood-CSF barrier into the inflammatory brain response. © 2006 Associação Arquivos de Neuro-Psiquiatria.
CITATION STYLE
Dorta-Contreras, A. J., Lewczuc, P., Noris-García, E., Interián-Morales, M. T., Tarrau, M. E. M., Padilla-Doca, B., & Escobar-Pérez, X. (2006). sICAM-1 in meningoencephalitis due to Angiostrongylus cantonensis. Arquivos de Neuro-Psiquiatria, 64(3 A), 589–591. https://doi.org/10.1590/S0004-282X2006000400011
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