Antitumour effect of cyclodepsipeptides from marine sponges

Abstract

Marine natural compounds with cyclodepsipeptidic structure are of great interest in drug discovery. The most intensively studied sponge-derived cyclodepsipeptide jasplakinolide (jaspamide) and its analogues are generally accepted as actin-polymerising and actin-stabilising drugs. Jasplakinolide is a potentially useful pharmacological tool for the study of actin organisation and dynamics in living cells. Also neamphamides and geodiamolides were tested to possess potent cytotoxic activities. These compounds represent an ideal starting point for scaffold mining and it is believed that additional screening of natural and unnatural jasplakinolide compounds and other cyclic depsipeptides will provide a route for significant future innovation.