Cross-linking in combination with mass spectrometry can be used as a tool for structural modeling of protein complexes and multidomain proteins. Although cross-links represent only weak structural constraints, the combination of a limited set of experimental cross-links with molecular docking/modeling is often sufficient to determine the structure of a protein complex or multidomain protein at low resolution.
CITATION STYLE
Mouradov, D., King, G., Ross, I. L., Forwood, J. K., Hume, D. A., Sinz, A., … Huber, T. (2008). Protein structure determination using a combination of cross-linking, mass spectrometry, and molecular modeling. Methods in Molecular Biology (Clifton, N.J.), 426, 459–474. https://doi.org/10.1007/978-1-60327-058-8_31
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