T226. CLINICAL PREDICTORS OF FUNCTIONAL CAPACITY IN TREATMENT RESISTANT SCHIZOPHRENIA PATIENTS: COMPARISON WITH RESPONDER PATIENTS, ROLE OF NEGATIVE SYMPTOMS, PROBLEM SOLVING DYSFUNCTIONS, AND NEUROLOGICAL SOFT SIGNS

Abstract

Background: Treatment Resistant Schizophrenia (TRS) patients show more severe impairments in community functioning compared to Antipsychotic Responder Schizophrenia (ARS) patients. The scope of this work was to assess whether TRS patients suffer from more severe alterations in functional capacity, i.e. the baseline potential of a patient to function in the community, and whether factors affecting functional capacity differ between TRS and ARS patients. Method(s): 60 out of 182 eligible patients were included. A multistep diagnostic procedure to separate TRS from ARS was then used. Patients were administered a range of assessment tools including (but not limited to): the PANSS; cognitive performances tests; the Specific Level of Functioning (SLOF); the Neurological Evaluation Scale (NES); the UCSD Performance- Based Skills Assessment (UPSA) extended version. Univariate and multivariate statistics were performed. Significance was set at p