Proteomic strategies for biomarker discovery: From differential expression to isoforms to pathways

Abstract

Proteomics technologies are improving at a great pace with the ultimate goal to allow the sensitive and comprehensive analysis of proteins in tissues and body fluids. The comparison of proteomes from two or more sources is still a challenging task but has already made significant inroads into biomarker discovery. This chapter describes strategies and platforms for biomarker discovery in mouse models and human specimens. We submit that the discovery of proteins that are differentially expressed will ultimately provide valuable information about the pathways involved in the pathobiology of psychiatric disorders. © Springer Science + Business Media, LLC 2008.