Utility of antifungal susceptibility testing and clinical correlations

Abstract

In this chapter, we review the available published data addressing the clinical relevance of antifungal susceptibility test results. By far the most data exist to support the clinical relevance of AFST results for Candida against fluconazole, and these data suggest that the clinical utility of this information mirrors that put forward for antibacterial susceptibility testing. Clinical relevance has also been demonstrated for selected other antifungal agents against Candida and Cryptococcus spp. By contrast, little direct support for the clinical utility of AFST for moulds is available.