Abstract
A series of benzo-fused heteroaryl-O-glucosides was synthesized and evaluated in SGLT1 and 2 cell-based functional assays. Indole-O-glucoside 10a and benzimidazole-O-glucoside 18 exhibited potent in vitro SGLT2 inhibitory activity. © 2005 Elsevier Ltd. All rights reserved.
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Zhang, X., Urbanski, M., Patel, M., Zeck, R. E., Cox, G. G., Bian, H., … Demarest, K. T. (2005). Heteroaryl-O-glucosides as novel sodium glucose co-transporter 2 inhibitors. Part 1. Bioorganic and Medicinal Chemistry Letters, 15(23), 5202–5206. https://doi.org/10.1016/j.bmcl.2005.08.067
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