Factors Related to Non-Adherence and Abandonment of Pulmonary Tuberculosis Treatment

Abstract

Objective: To analyze the evidence available in the literature on factors related to non-adherence to directly observed treatment by patients with pulmonary tuberculosis. Methods: This is an integrative literature review. The search was conducted between August 2019 and May 2020, by accessing the MEDLINE, LILACS, BDENF, BINACIS, IBECS, PUBMED, SCOPUS, and WEB OF SCIENCE databases, as well as via the SCIELO virtual library, selecting articles published between 2009 and 2019. Results: From the 1664 pre-analyzed studies, 57 articles that met the research question were identified and selected. Following data extraction, non-adherence factors were stratified into five categories, namely: Patient-related factors, socioeconomic aspects, factors related to treatment, factors related to healthcare providers/service, and knowledge aspects, which presented a correspondence of 49, 33, 41, 23, and 20 articles, respectively. Conclusion: This study enabled an analysis of the scientific evidence regarding factors related to non-adherence to directly observed treatment by patients with pulmonary tuberculosis. It is concluded that the multifaceted range of aspects associated with such a research issue can be synthesized into factors related to patients, socioeconomic aspects, factors concerning treatment, factors related to healthcare providers/ service, and aspects inherent to knowledge.