Secondary metabolites from the Endophytic fungi Fusarium decemcellulare F25 and their antifungal activities

Abstract

Seven new compounds, including three isocoumarins (1–3), three pyrrolidinone derivatives (8–10), and one pentaene diacid (15), together with 13 known compounds, were isolated from the rice culture of the endophytic fungus Fusarium decemcellulare F25. Their structures and stereochemistry were established using HRESIMS, NMR, electronic circular dichroism (ECD) calculations, and single-crystal X-ray diffraction. The possible biosynthetic pathways for compounds 1–3 and 8–10 were proposed. The antifungal efficacies of compounds 1 ̶ 20 were evaluated against Colletotrichum musae, and compounds 13, 14, and 17 exhibited inhibitory activities against C. musae with MIC values of 256, 64 and 128 μg/mL, respectively.