Comparative Efficacy of Tagetes erecta and Centella asiatica Extracts on Wound Healing in Albino Rats

Abstract

The study was undertaken to evaluate the comparative efficacy of hydroalcoholic extracts of leaves of Ta- getes erecta(T. erecta) and aerial parts of Centella asiatica(C. asiatica) on Excision, Incision and Dead space wound models in albino rats. Extract of T. erectaand C. asiatica (P< 0.001) showed significant in-crease in rate of wound contraction, epithelization and formation of scar faster in excision wound model compare to control group. T. erectaextract (250 and 500 mg/kg) showed significantly increased the wound breaking strength in incision wound model and wet and dry granulation tissue weights, breaking strength in a dead space wound model compare to control and C. asiaticatreated group (P< 0.001). In this investigation the work is conclude that the comparisonmade between the above two plants, the T. erecta extract showed potent wound healing activity then the reported C. asiatica in different wound parameters.