Microbial Source of Fibrinolytic Protease and Its Biotechnological Potential

Abstract

Many fi brinolytic proteases are isolated and purifi ed from various sources. These fi brinolytic proteases have biotechnological applications to treat cardiovascular diseases. Fibrinolytic enzyme, Actinokinase is isolated and produced from thermophilic Streptomyces megasporus SD5 . The fi brinolytic enzyme is serine endopeptidase. The proteolytic enzyme which acts on different substrates casein, azocasein, fi brin etc. Enzyme is plasminogen independent. Some of these properties are studied & summarized for isolated fi brinolytic protease. Various fi brinolytic proteases also isolated from different resources and their biochemical characterization is reported in the literatures. In general proteases are also used in food, pharmaceutical, cosmetics and environmental industry. Overall all proteases have been used for application prospectives. There are many fi brinolytic proteases discovered till todate. These agents need to check thoroughly to their biochemical properties and substrate base catalysis. Therefore microbial fi brinolytic proteases are used for therapeutic approach of medical interest. The diverse microbial population produces the fi brinolytic proteases. The properties of fi brinolytic enzymes are described in different literatures. Many reported fi brinolytic enzymes are plasminogen activator and some are fi brin specifi c in nature. These enzymes had drawbacks such as bleeding complications, haemorragic in nature and expensive in nature. So search of new fi brinolytic proteases is still in continued for better molecule.