Antimicrobial and Anti-Inflammatory Properties of Silver Nanoparticles in Burn Treatment

Abstract

Burn is one of the most common injuries which leading to high morbidity and mortality. Inflammation and infection involve in burn pathophysiology. Inflammation occurs in burn mainly due to release of inflammatory cytokines, while infection occurs when skin barrier damage and immune system is compromised due to suppression of neutrophils and T cells. In previous studies, silver nanoparticles (AgNPs) exhibit antimicrobial and anti-inflammatory properties through several mechanism. Antimicrobial mechanism of AgNPs including the damage of cell wall and alteration inner part of cell, while anti-inflammatory mechanism of AgNPs is by reducing pro-inflammatory cytokines. Therefore, silver nanoparticles can be reasonable treatment for burn.