Background: There are limited data on Coronavirus disease 2019 (COVID-19) in solid organ transplant patients, especially in heart transplant recipients, with only a few case reports and case series described so far. Heart transplant recipients may be at particular high risk due to their comorbidities and immunosuppressed state. Case presentation: This report describes the clinical course and the challenging management of early COVID-19 infection in two heart transplant recipients who tested positive for the SARS-CoV-2 virus in the perioperative period of the transplant procedure. The two patients developed a severe form of the disease and ultimately died despite the initiation of an antiviral monotherapy with hydroxychloroquine coupled with the interruption of mycophenolate mofetil. Conclusions: These two cases illustrate the severity and poor prognosis of COVID-19 in the perioperative period of a heart transplant. Thorough screening of donors and recipients is mandatory, and the issue of asymptomatic carriers needs to be addressed.
CITATION STYLE
Tchana-Sato, V., Ancion, A., Tridetti, J., Sakalihasan, N., Hayette, M. P., Detry, O., … Lancellotti, P. (2021). Clinical course and challenging management of early COVID-19 infection after heart transplantation: case report of two patients. BMC Infectious Diseases, 21(1). https://doi.org/10.1186/s12879-021-05793-6
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