Mangrove derived fungal endophytes - A chemical and biological perception

Abstract

The potential of mangrove-derived endophytic fungi as a promising source of diverse and structurally unprecedented bioactive natural products is unquestionable and continues to attract considerable attention. This review highlights new bioactive mangrove fungal metabolites and known compounds with hitherto unreported biological activities described during the last 10 years. The compounds are categorized according to their reported biological activities, including cytotoxic, anti-infective, in addition to a wide range of miscellaneous activities such as protein kinase, α-glucosidase, acetylcholinesterase and tyrosinase inhibitory activities, as well as antiangiogenic and neovascularisation effects, radical scavenging, DNA-binding affinity, and calcium and potassium channel blocking activity. © 2013 Mushroom Research Foundation.