A general synthesis of bis-indolylpiperazine-2,5-diones

Abstract

The one-pot synthesis of three dragmacidin derivatives is reported. Sarcosine anhydride (4) is brominated and immediately reacted with the corresponding indole to produce the products, namely 3,6-bis(5'-methoxy-3'- indolyl)-1,4-dimethylpiperazine-2,5- dione (1), 3,6-bis(7'-methyl-3'-indolyl)-1, 4-dimethylpiperazine-2,5-dione (2) and 3,6-bis-(6'-chloro-3'-indolyl)-1,4- dimethylpiperazine-2,5-dione (3), which are characterized by 1H-NMR. © 2012 by the authors; licensee MDPI, Basel, Switzerland.