Primary neuroendocrine carcinoma of the breast: A rare presentation and review of the literature

6Citations
Citations of this article
14Readers
Mendeley users who have this article in their library.

Abstract

Primary neuroendocrine carcinoma of the breast (NEBC) is a very rare occurrence accounting for less than 0.1% of all breast cancers. Typically, the tumor presents with ER- and PgR-positive and HER-2-negative status. Despite its luminal type, NEBC is associated with a more aggressive clinical course and poorer prognosis compared to the other types of invasive breast cancer. Clinical and radiological findings are nonspecific. The most common clinical manifestation is a palpable mass whereas in mammography the tumor most commonly appears as a round or oval mass without spiculated margins. Herein, a very rare case of NEBC is described in an asymptomatic patient who presented with an area of architectural distortion and the presence of microcalcifications that was incidentally detected on a screening mammography. A review of the literature has also been conducted. The diagnosis of NEBC requires a thorough investigation to exclude the possibility of a metastatic neuroendocrine tumor from another site because the two entities require different treatment approaches. Due to the rarity of the disease, the optimal therapeutic approach has not been clearly defined. Surgical resection is the mainstay of treatment. Further research is needed to better understand the molecular characteristics of NEBC and identify novel targeted therapies.

Author supplied keywords

References Powered by Scopus

Primary carcinoid tumor of the breast. A report of eight patients

197Citations
N/AReaders
Get full text

Small cell carcinoma of the breast: A clinicopathologic and immunohistochemical study of nine patients

180Citations
N/AReaders
Get full text

Invasive neuroendocrine carcinoma of the breast: A distinctive subtype of aggressive mammary carcinoma

150Citations
N/AReaders
Get full text

Cited by Powered by Scopus

Clinicopathological Characteristics and Prognostic Profiles of Breast Carcinoma with Neuroendocrine Features

4Citations
N/AReaders
Get full text

Primary neuroendocrine carcinoma of the breast with paraneoplastic thrombocytosis; a rare case report

1Citations
N/AReaders
Get full text

Primary neuroendocrine tumor of the breast: A case report

0Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Salemis, N. S. (2020). Primary neuroendocrine carcinoma of the breast: A rare presentation and review of the literature. Intractable and Rare Diseases Research. International Advancement Center for Medicine and Health Research Co., Ltd. https://doi.org/10.5582/irdr.2020.03046

Readers over time

‘21‘22‘24‘2502468

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 3

75%

Professor / Associate Prof. 1

25%

Readers' Discipline

Tooltip

Medicine and Dentistry 5

83%

Agricultural and Biological Sciences 1

17%

Save time finding and organizing research with Mendeley

Sign up for free
0