Influence on Blood Pressure of Renal Isografts between Spontaneously Hypertensive and Normotensive Rats, Utilizing the F1 Hybrids

Abstract

The F1 hybrids (F1) of spontaneously hypertensive rats (SHR) and Wistar rats (W), whose kidneys were transplanted from SHR at the age of 10 weeks and 20 weeks, showed significant elevation of blood pressure (BP) for 11 weeks after the transplantation. In F1 with W or F1 kidneys BP was decreased near to the normal level. F1 whose kidneys were transplanted from SHR or W showed low renin activity both in plasma and the kidney. It is suggested that BP of SHR is probably determined by the renal prohypertensive factor(s) other than renin influencing on sympathetic nerves through central nervous systems. © 1978, International Heart Journal Association. All rights reserved.