Objective: The present study aimed to evaluate the influence of the relative composition of trace elements and vitamins in physicochemical stability of neonatal parenteral nutrition. Material and methods: Three formulations for neonatal administration were selected; the main variable was the presence of trace elements and vitamins. The analyses where carried out immediately after preparation and at 24 h, 48 h, 72 h and 7 days after preparation. Three methods were selected to determine globule size: light obscuration, dynamic light scattering and optical microscopy. Complementary evaluation including visual inspection, determination of pH and osmolarity, peroxide levels and measurements of zeta potential were also performed. Results: There was an observable alteration in color and phase separation in the PN stored at 25°C and 40°C. Neither globule size pattern, nor any other physicochemical characteristic evaluated appeared to be considerably altered in any of the analyzed formulations even after 7 days of storage at 5°C. Globule size in all the PN studied was consistent with the established limit, below 500 nm by DLS measurement, and PFAT5 was below 0.05% under all storage temperatures. Conclusion: Concomitant presence of trace elements and vitamins in the same neonatal formulation did not alter the evaluated aspects of stability. © 2012 Lobo et al.; licensee BioMed Central Ltd.
CITATION STYLE
Lobo, B. W., Da Veiga, V. F., Cabral, L. M., Michel, R. C., Volpato, N. M., & De Sousa, V. P. (2012). Influence of the relative composition of trace elements and vitamins in physicochemical stability of total parenteral nutrition formulations for neonatal use. Nutrition Journal, 11(1). https://doi.org/10.1186/1475-2891-11-26
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