Split ends in CML: Divergent roles of Hes1

Abstract

Hairy enhancer of split 1 (Hes1), a basic helix-loop-helix transcription factor mediator of Notch signaling, maintains hematopoietic and neuronal stem cell self-renewal as well as fetal T-cell and malignantCMLprogenitor immaturity, according to Nakahara and colleagues in this issue of Blood.