Metallothionein immunoexpression in non-syndromic and syndromic keratocystic odontogenic tumour

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Abstract

Background: To compare the metallothionein (MT) immunoexpression in non-syndromic and syndromic keratocystic odontogenic tumour (KOT), to correlate MT with cellular proliferation, and to evaluate the influence of inflammation in MT. Material and Methods: Fourteen cases of KOT were submitted to immunohistochemistry for MT and Ki-67 analysis. The lesions were grouped according to their grade of inflammation, and statistical analysis was performed. Results: MT was higher in non-syndromic KOT than in syndromic KOT (p<0.05). No statistical difference in Ki-67 could be identified; however, an inverse correlation was observed between MT and Ki-67 in both lesions. When analysing inflammation, non-syndromic KOT showed no differences in either MT or Ki-67. Conclusions: The MT immunophenotype of syndromic KOT was different from non-syndromic KOT. MT might not be involved in the proliferation control of both KOT. MT and Ki-67 immunoexpressions proved to be unaffected by inflammation in non-syndromic KOT.

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APA

Johann, A. C. B. R., Caldeira, P. C., Caliari, M. V., Gomez, R. S., Aguiar, M. C. F., & Mesquita, R. A. (2015). Metallothionein immunoexpression in non-syndromic and syndromic keratocystic odontogenic tumour. Medicina Oral, Patologia Oral y Cirugia Bucal, 20(4), e408–e412. https://doi.org/10.4317/medoral.20418

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