Glutamine is made from glutamine and ammonia through a biochemical reaction, catalyzed by enzyme glutamine synthetase [1]. In fact, GLN is crucial in the regulation of amino acid homeostasis. GLN provides the amide-group required for the synthesis of metabolites, such as the amino-sugars, purines, pyrimidines and nucleotides. In addition, Gln is an important nutrient for rapidly proliferating cells, including enterocytes and lymphocytes [2]. The relevance of GLN is also related to enhancing the availability of these metabolites, e.g. the synthesis of the antioxidant glutathione, and the synthesis of citrulline and arginine [3], and the resultant production of the vasodilator nitric oxide.
CITATION STYLE
Al-Banna, N. A., & Lehmann, C. (2015). Dipeptide-bound glutamine and the intestinal microcirculation in sepsis. In Glutamine in Clinical Nutrition (pp. 383–398). Springer New York. https://doi.org/10.1007/978-1-4939-1932-1_29
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