Growth hormone receptor and serum binding protein: Purification, cloning and expression

Abstract

A putative growth hormone receptor from rabbit liver and the growth hormone binding protein from rabbit serum have the same ammo-terminal amino-acid sequence, indicating that the binding protein corresponds to the extracellular hormone-binding domain of the liver receptor. The complete amino-acid sequences derived from complementary DNA clones encoding the putative human and rabbit growth hormone receptors are not similar to other known proteins, demonstrating a new class of transmembrane receptors. © 1987 Nature Publishing Group.