Oral submucous fibrosis

Abstract

Oral submucous fibrosis (OSMF) is a chronic, complex potentially malignant disorder. It is characterized by juxtaepithelial inflammatory reaction. It is characterized by inflammation and a progressive fibrosis of the lamina propria and deeper connective tissues. The etiology is multifactorial tobacco, areca nut chewing, consumption of chilies, genetics, and nutritional deficiency. There is a burning sensation followed by blisters, stomatitis, stiffness of tissues, and difficulty in mouth opening. This review attempts to give a comprehensive outline of the classification, clinical and histopathological features, etiology, pathogenesis, and treatment of OSMF.