Abstract
Bioactivity guided isolation of dichloromethane extract of Alternaria alternata identified tenuazonic acid (1) as potentially active against Mycobacterium tuberculosis H37Rv, MIC at 250 μg/mL concentration. This active metabolite 1, was also evaluated for osmotic hemolysis using the erythrocyte as a model system. It was observed that this fungal metabolite showing antitubercular activity exhibited concentration dependent toxicity to human erythrocytes.
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CITATION STYLE
Sonaimuthu, V., Parihar, S., Prakash Thakur, J., Luqman, S., Saikia, D., Chinotiya, C. S., … Negi, A. S. (2011). Tenuazonic acid: a promising antitubercular principle from Alternaria alternate. Microbiology Research, 2(1), 17. https://doi.org/10.4081/mr.2011.e17
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