Intestinal and systemic immunity to rotavirus in animal models and humans

Abstract

Rotavirus (RV) is an enteric virus causing severe diarrhea in young infants and children worldwide. After RV infection, mainly enteric, but also systemic immune responses are elicited. Recently, extraintestinal RV antigen was observed in various animal models and humans, explaining the induction of systemic immunity after infection. This chapter will summarize the B and T cell responses and innate immunity to RV after infection in animal models and humans. Additionally, current human rotavirus (HRV) vaccines and correlates of protection after vaccination will be discussed.