SARS-CoV-2–Reactive Mucosal B Cells in the Upper Respiratory Tract of Uninfected Individuals

  • Liu Y
  • Budylowski P
  • Dong S
  • et al.
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Abstract

SARS-CoV-2 is a respiratory pathogen that can cause severe disease in at-risk populations but results in asymptomatic infections or a mild course of disease in the majority of cases. We report the identification of SARS-CoV-2–reactive B cells in human tonsillar tissue obtained from children who were negative for coronavirus disease 2019 prior to the pandemic and the generation of mAbs recognizing the SARS-CoV-2 Spike protein from these B cells. These Abs showed reduced binding to Spike proteins of SARS-CoV-2 variants and did not recognize Spike proteins of endemic coronaviruses, but subsets reacted with commensal microbiota and exhibited SARS-CoV-2–neutralizing potential. Our study demonstrates pre-existing SARS-CoV-2–reactive Abs in various B cell populations in the upper respiratory tract lymphoid tissue that may lead to the rapid engagement of the pathogen and contribute to prevent manifestations of symptomatic or severe disease.

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CITATION STYLE

APA

Liu, Y., Budylowski, P., Dong, S., Li, Z., Goroshko, S., Leung, L. Y. T., … Ehrhardt, G. R. A. (2021). SARS-CoV-2–Reactive Mucosal B Cells in the Upper Respiratory Tract of Uninfected Individuals. The Journal of Immunology, 207(10), 2581–2588. https://doi.org/10.4049/jimmunol.2100606

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