Synthesis and acaricidal activity of new 1H-pyrazole-4-carboxamide derivatives

Abstract

To find new lead compounds with high acaricidal bioactivity, ten new 1H-pyrazole-4-carboxamide derivatives were designed and synthesized by combining with the 1,3,5-trimethyl-1H-pyrazole-4-carboxamide moiety in pyflubumide and diaryl ether moiety in flufenoxuron. Their structures were confirmed by 1H NMR, MS and elemental analyses. The acaricidal activities of these compounds were evaluated by pesticide bioassay procedure. The results showed that most of title compounds exhibited significant effect against Tetranychus cinnabarinus with 90.0% death rate at 500 mg/L. © 2013 Chinese Chemical Society & SIOC, CAS.