The effect of age and breast density on the sensitivity of mammography

Abstract

This study examines the extent to which differences in sensitivity by age can be attributed to variations in breast density using a reliable, computer-assisted, continuous measure of per cent breast density. We included women aged 40–79 years, not using hormone replacement therapy, who attended BreastScreen Victoria for first-round screening mammography in 1994 and 1995 (1002 breast cancers) and for subsequent-round screening (381 breast cancers) in 1995 and 1996. True positive cancers were invasive breast cancers diagnosed at screening and false negative cancers were cancers diagnosed within 24 months of a negative screening examination