Apoptosis and apoptosis-associated perturbations of peripheral blood lymphocytes during HIV infection: Comparison between AIDS patients and asymptomatic long-term non-progressors

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Abstract

This study was designed to compare the degree of lymphocyte apoptosis and Fas-Fas ligand (FasL) expression in AIDS patients and long-term non-progressors (LTNPs) and correlate these parameters with apoptosis-associated perturbations in lymphocyte function. LTNPs had a lower frequency of apoptotic CD4+ and CD8+ T cells compared with subjects with AIDS. This correlated with a lower frequency of cells expressing Fas and FasL. The frequency of selected lymphocyte populations exhibiting a disrupted mitochondrial transmembrane potential (Δψ(m)) and increased superoxide generation was lower in LTNPs than in patients with AIDS; these abnormalities were associated with lower levels of caspase-1 activation in LTNPs. The results indicate a significantly reduced level of apoptosis and apoptosis-associated parameters in LTNPs than in patients developing AIDS. Based on these findings, a crucial role for mitochondria can be predicted in the process of lymphocyte apoptosis during the evolution of AIDS.

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Moretti, S., Marcellini, S., Boschini, A., Famularo, G., Santini, G., Alesse, E., … De Simone, C. (2000). Apoptosis and apoptosis-associated perturbations of peripheral blood lymphocytes during HIV infection: Comparison between AIDS patients and asymptomatic long-term non-progressors. Clinical and Experimental Immunology, 122(3), 364–373. https://doi.org/10.1046/j.1365-2249.2000.01375.x

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