Abstract
This chapter reviews the role of c-Src tyrosine kinase in mammary tumor progression. In addition to highlighting the molecular mechanism by which c-Src is activated, we explore the evidence of supporting a role for c-Src in both murine and human breast cancers. In particular, this review highlights the use of mouse models to resect the role of c-Src in mammary tumor progression. These genetic analyses provide important insight into the role of c-Src signaling pathway in oncogene-induced mammary tumor progression.
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CITATION STYLE
Marcotte, R., & Muller, W. J. (2012). Src family tyrosine kinases: Implications for mammary tumor progression. In Genetically Engineered Mice for Cancer Research: Design, Analysis, Pathways, Validation and Pre-Clinical Testing (pp. 331–352). Springer New York. https://doi.org/10.1007/978-0-387-69805-2_16
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