A primary function of B lymphocytes is immunoglobulin production; however, the therapeutic benefit of B cell depletion in autoimmune diseases previously thought to be T cell mediated suggests that some B cells fulfill other roles in autoimmunity. We examined the recently identified human B1 cell population for T cell stimulatory activity. We found two kinds of B1 cells that are distinguished by multiple surface markers and distinct transcriptomic profiles. In both umbilical cord and adult peripheral blood, a CD11b + subset constitutes ~1 out of every 8-10 B1 cells, whereas a CD11b - subset constitutes the remaining B1 cells. These B1 cell populations differ functionally. CD11b - B1 cells spontaneously secrete much more IgM than CD11b + B1 cells. In contrast, CD11b + B1 cells express more CD86, and more efficiently stimulate allogeneic CD4 + T cell expansion, than CD11b - B1 cells. The frequency of these CD11b + B1 cells is markedly elevated in lupus patients. CD11b + B1 cells in lupus patients express more CD86 and have increased T cell stimulating activity in disease. This work distinguishes a novel, T cell.interacting B1 cell population whose abundance and activity may be a reflection of, and a therapeutic target in, autoimmune disease. © 2011 Griffin and Rothstein.
CITATION STYLE
Griffin, D. O., & Rothstein, T. L. (2011). A small cd11b + human B1 cell subpopulation stimulates T cells and is expanded in lupus. Journal of Experimental Medicine, 208(13), 2591–2598. https://doi.org/10.1084/jem.20110978
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