Effects of dimethyl phthalate (DMP) on serum sex hormone levels and apoptosis in C57 female mice

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Abstract

Background: The effects of dimethyl phthalate (DMP) on the reproductive system of mammal females are unclear because no studies have been conducted on this topic. Methods: In this study, 40 C57 female mice were used as experimental subjects and evenly divided into 8 groups, which were fed with mixed DMP (0, 0.5, 1, and 2 g/kg bw/day) and corn oil. After 20 days and 40 days of gavage, the mice were weighed and their individual ovary organ coefficients measured. Results: Changes were discovered on progesterone, estradiol, follicle-stimulating hormone and luteinizing hormone in mouse serum, and on the apoptosis rate of ovarian granulosa cells. Conclusions: Prolonged exposure to DMP led to decreased secretion of FSH hormones and increased secretion of E2 and LH hormones. Furthermore, DMP interfered with the pituitary-ovary axis and increased the apoptosis rate of ovarian granulosa cells. Therefore, prolonged exposure to DMP is likely to have negative effects on reproduction and development.

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Mei, Y., Rongshuang, M., Ruizhi, Z., Hongyuan, H., Qiyue, T., & Shuhua, Z. (2019). Effects of dimethyl phthalate (DMP) on serum sex hormone levels and apoptosis in C57 female mice. International Journal of Endocrinology and Metabolism, 17(2). https://doi.org/10.5812/ijem.82882

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