Ribosomal RNA genes are highly repetitive and therefore not annotated in genome assemblies. We did recently analyze the epigenetic and architectural regulation of murine ribosomal genes by the Transcription Termination Factor I and made use of genome-wide histone modification ChIP-seq data. This method paper describes how repetitive genomic regions can be integrated into custom genomic assemblies and be used with genome-wide profiling data.
CITATION STYLE
Schwartz, U., & Längst, G. (2016). Bioinformatic analysis of ChiP-seq data on the repetitive ribosomal RNA gene. In Methods in Molecular Biology (Vol. 1455, pp. 225–230). Humana Press Inc. https://doi.org/10.1007/978-1-4939-3792-9_17
Mendeley helps you to discover research relevant for your work.