Oxidative stress and inflammation play a central role in the onset and development of liver diseases irrespective of the agent causing the hepatic impairment. The monocyte chemoattractant protein-1 is intimately involved in the inflammatory reaction and is directly correlated with the degree of hepatic inflammation in patients with chronic liver disease. Recent studies showed that hepatic paraoxonase-1 may counteract the production of the monocyte chemoattractant protein-1, thus playing an anti-inflammatory role. The current review summarises experiments suggesting how paraoxonase-1 activity and expression are altered in liver diseases, and their relationships with the monocyte chemoattractant protein-1 and inflammation. © Humana Press, a part of Springer Science+Business Media, LLC 2010.
CITATION STYLE
Camps, J., Marsillach, J., Rull, A., Alonso-Villaverde, C., & Joven, J. (2010). Interrelationships between paraoxonase-1 and monocyte chemoattractant protein-1 in the regulation of hepatic inflammation. Advances in Experimental Medicine and Biology. Springer New York LLC. https://doi.org/10.1007/978-1-60761-350-3_2
Mendeley helps you to discover research relevant for your work.