Optimasi Pembuatan Scaffold dengan Struktur Pori-Pori Beraturan Menggunakan Metode Response Surface Method

Abstract

Injuries caused by traffic accidents can cause victims to suffer broken bones, disability, and even death. Victims who have bone damage can be cured by bone restoration, which is by implanting artificial bone in damaged bone tissue. One example of an implant method is to make a scaffold made from hydroxyapatite (HA) biomaterials. The scaffold is designed based on the size of the bone damage, and is printed with a 3D ABEF (Aqueous-based extraction fabrication) printing machine. Research related to optimizing scaffold making is done using the Response Surface Method, using plot contour graphs and response optimizers. Optimized scaffold manufacturing parameters are the axis of movement speed, extrusion speed, and nozzle diameter. This analysis aims to find the smallest error value from making scaffold, so we get the optimal form of scaffold from scaffold dimensions and cavity size. Based on the research results, optimization of scaffold making using the Response Surface Method produces a combination of scaffold forming parameters, with an extrusion speed of 30 mm / s, an axis speed of 30 mm / s, and a nozzle diameter of 0.8 mm.