Mucin 1 gene (MUC1) and gastric-cancer susceptibility

N/ACitations
Citations of this article
27Readers
Mendeley users who have this article in their library.

Abstract

Gastric cancer (GC) is one of the major malignant diseases worldwide, especially in Asia. It is classified into intestinal and diffuse types. While the intestinal-type GC (IGC) is almost certainly caused by Helicobacter pylori (HP) infection, its role in the diffuse-type GC (DGC) appears limited. Recently, genome-wide association studies (GWAS) on Japanese and Chinese populations identified chromosome 1q22 as a GC susceptibility locus which harbors mucin 1 gene (MUC1) encoding a cell membrane-bound mucin protein. MUC1 has been known as an oncogene with an anti-apoptotic function in cancer cells, however, in normal gastric mucosa, it is anticipated that the mucin 1 protein has a role in protecting gastric epithelial cells from a variety of external insults which cause inflammation and carcinogenesis. HP infection is the most definite insult leading to GC, and a protective function of mucin 1 protein has been suggested by studies on Muc1 knocked-out mice. © 2014 by the authors, licensee MDPI, Basel, Switzerland.

Cite

CITATION STYLE

APA

Saeki, N., Sakamoto, H., & Yoshida, T. (2014, May 7). Mucin 1 gene (MUC1) and gastric-cancer susceptibility. International Journal of Molecular Sciences. MDPI AG. https://doi.org/10.3390/ijms15057958

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free