Attenuation of α-synuclein aggregation by catalytic photo-oxygenation

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Abstract

We developed catalyst 11 to promote selective photo-oxygenation of α-synuclein amyloid and attenuate its aggregation. Catalyst 11 effectively oxygenated both small and large aggregates. The oxygenated α-synuclein exhibited lower seeding activity than intact α-synuclein. This study corroborates the feasibility of catalytic photo-oxygenation as an anti-synucleinopathy strategy.

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Iwai, A., Nakamura, R., Tomizawa, I., Mitsunuma, H., Hori, Y., Tomita, T., … Kanai, M. (2023). Attenuation of α-synuclein aggregation by catalytic photo-oxygenation. Chemical Communications, 59(38), 5745–5748. https://doi.org/10.1039/d3cc00665d

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