Background: The etiology of traumatic ulcerative granulomas with stromal eosinophilia (TUGSE) is not clear, traumatic irritation having advocated as the most likely cause. TUGSEs are typically self-limiting slow-healing lesions of the oral mucosa with unclear pathogenesis, commonly manifesting as a rapidly developing, long-lasting ulcer. Case presentation: Here we report a controversial case of a self-healing lesion of the tongue in a 57 year-old woman. A clonal T-cell proliferation and CD30 negative immunohistochemical (IHC) profile could be documented. Discussion and conclusion: In view of the very peculiar clinical and histological features, a retrospective diagnosis of a TUGSE with scarce eosinophilic infiltrate (possibly in regression), displaying CD30- T-clonal proliferation was eventually rendered. The patient did not report signs of recurrence after a 3-year follow-up period.
CITATION STYLE
Setti, G., Martella, E., Mancini, C., Vescovi, P., Magnoni, C., Bellini, P., … Meleti, M. (2019). Self-healing CD30- T-clonal proliferation of the tongue: Report of an extremely rare case. BMC Oral Health, 19(1). https://doi.org/10.1186/s12903-019-0875-5
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