Hepcidin in Hemodialysis Patients: An Update Review

Abstract

Hepcidin levels are associated with complications in chronic kidney disease patients, particularly patients on hemodialysis. However, the correlation between hepcidin levels and hemodialysis therapy is still unclear. This article will describe the physiological regulation of hepcidin and abnormalities in hepcidin levels in chronic kidney disease patients. We alsodiscusses the relationship between hepcidin levels and hemodialysis therapy in chronic kidney disease patients in this article. An increase in hepcidin can occur in patients on hemodialysis therapy, where the patient's estimated glomerular filtration rate is so low that hepcidin cannot be eliminated. On the other hand, hemodialysis can act as a substitute for the kidney to eliminate hepcidin. However, the decrease in hepcidin levels after hemodialysis did not last long. Therefore, to prevent complications, iron therapy should be given immediately.