Laminin Enriched Scaffolds for Tissue Engineering Applications

Abstract

Laminin (LM) is heterotrimeric large molecular weight glycoprotein that forms a crucial component of the basal lamina (or basement membrane) of most tissues. LMs are integral for cell adhesion, proliferation, survival, migration, and differentiation. Several studies have used a LM-coated 2D substrate for the culture and maintenance of stem cell phenotype in vitro. Recent studies have reported that LM can also be incorporated in 3D scaffolds for tissue engineering applications. This article illustrates the bioactivity and regenerative potential of LM protein in 3D scaffolds for skeletal muscle, nerve, vascular, and intervertebral-disc regeneration.