Novel COVID-19 Diagnosis Delivery App Using Computed Tomography Images Analyzed with Saliency-Preprocessing and Deep Learning

Abstract

This app project was aimed to remotely deliver diagnoses and disease-progression information to COVID-19 patients to help minimize risk during this and future pandemics. Data collected from chest computed tomography (CT) scans of COVID-19-infected patients were shared through the app. In this article, we focused on image preprocessing techniques to identify and highlight areas with ground glass opacity (GGO) and pulmonary infiltrates (PIs) in CT image sequences of COVID-19 cases. Convolutional neural networks (CNNs) were used to classify the disease progression of pneumonia. Each GGO and PI pattern was highlighted with saliency map fusion, and the resulting map was used to train and test a CNN classification scheme with three classes. In addition to patients, this information was shared between the respiratory triage/radiologist and the COVID-19 multidisciplinary teams with the application so that the severity of the disease could be understood through CT and medical diagnosis. The three-class, disease-level COVID-19 classification results exhibited a macro-precision of more than 94.89% in a two-fold cross-validation. Both the segmentation and classification results were comparable to those made by a medical specialist.